Akihiko Yamagishi

Tokyo University of Pharmacy and Life Science, Professor., Ph.D.


  • Tokyo University of Pharmacy and Life Science
  • Department of Molecular Biology
  • 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan
  • Phone: +81-426-76-7139
  • Fax: +81-426-76-7145
  • E-mail: yamagish@ls.toyaku.ac.jp
    (When you send e-mail by PC software, please add "ls.toyaku.ac.jp" after "@")

Education and Positions

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Present studies

Early evolution of life

  • Searching hyper-thermophiles form marine hydrothermal area
  • Analyzing genes and proteins of hyperthermophiles
  • Making ancestral enzymes
  • Searching microbes at high atmosphere

Evolutionary process forming eukaryotic cells

  • Analyzing cell structure of Thermoplasma
  • Analyzing ether-lipid biosynthetic pathway
  • We have found thermoplasma related PCR clones in termite gut

Protein engineering: thermal stability of proteins

  • Analyzing thermal stability of proteins of thermophilic microbes
  • Molecular dynamics calculations by using MD engines
  • Trying to make the way of designing proteins at will

Evolutionary molecular engineering

  • To make component for nano technology
  • To make proteins thermo stable
  • Low temperature adaptation of thermophilic enzymes
  • Designing new substrate specificity of enzymes
  • To develop genetic engineering system for thermophiles

Copyright(c)2005-2007 Lab. Cellular Biochem., Dep. Mol. Biol., Tokyo Univ. Pharm. Life Sci. all right reserved.

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