2021

 
 
Toyofuku, M., Fujinaga, D.,  Inaba, K.,  Funahashi, T., Fujikawa, Inoue, H., Kataoka, H., Niwa, R., Ono, H. 
The plant-derived triterpenoid, cucurbitacin B, but not cucurbitacin E, inhibits the developmental transition associated with ecdysone biosynthesis in Drosophila melanogaster
J. Insect Physiol. 134, 104294
DOI: https://doi.org/10.1016/j.jinsphys.2021.104294
 
 
Yun, Y.S., Shioura, M., Hitotsuyanagi, Y., Yotsumoto, S., Takahashi, Y., Aoyagi, Y., Kinoshita, T., Takeya, K., and Inoue, H.
Garcinielliptone G from  Garcinia subelliptica i nduces a poptosis in acute leukemia cells.
Molecules 26, 2422.
DOI: https://doi.org/10.3390/
molecules26092422
 
 
Koiwai, K., Morohashi, K., Inaba, K., Ebihara, K., Kojima, H., Okabe, T., Yoshino, R., Hirokawa, T., Nampo, T., Fujikawa, Y., Inoue, H., Yumoto, F., Senda, T., Niwa, R.
Non-steroidal inhibitors of Drosophila melanogaster steroidogenic glutathione S-transferase Noppera-bo.
J. Pestic. Sci. D20-072.
DOI:  https://doi.org/10.1584/jpestics.D20-072

 
 

2020

 
 
Nagata, A., Itoh, F., Sasho, A., Sugita, K., Suzuki, R., Hinata, H., Shimoda, Y., Suzuki, E., Maemoto, Y., Inagawa, T., Fujikawa, Y., Ikeda, E., Fujii, C., and Inoue, H.
The evolutionarily conserved deubiquitinase UBH1/UCH-L1 augments DAF7/TGF-β signaling, inhibits dauer larva formation, and enhances lung tumorigenesis.
J. Biol. Chem. 295(27) 9105-9120.

 
 
Koiwai1, K., Inaba, K., Morohashi, K., Enya, S., Arai, R., Kojima, H., Okabe, T., Fujikawa, Y., Inoue, H., Yoshino, R., Hirokawa, T., Kato, K., Fukuzawa, K., Shimada-Niwa, Y., Nakamura, A., Yumoto, F., Senda, T., and Niwa, R.  (2020)
An integrated approach to unravel a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo.
J. Biol. Chem., 295(20):7154-7167. 
DOI: 10.1074/jbc.RA119.011463
PMID:32241910
 
 
Mori, M., Fujikawa, Y., Inoue, H. (2020)
Convenient synthesis of regioisomerically pure 5- and 6-functionalized xanthene dyes via SNAr reaction and comparison of their reactivity towards click reaction.
Tetrahedron, 76(15) Article 131087. 
Link
 
 
Shoda, T., Ohoka, N., Tsuji, G., Fujisato, T., Inoue, H., Demizu, Y., Naito, M., Kurihara, M. (2020)
Targeted protein degradation by chimeric compounds using hydrophobic E3 ligands and adamantane moiety.
Pharmaceuticals, 13(3), 34. 
DOI: 10.3390/ph13030034 
 
 

2019

 
 
Fujikawa, Y., Terakado, K., Nampo, T., Mori, M., and Inoue, H. (2019)
4-Bromo-1,8-naphthalimide derivatives as fluorogenic substrates for live cell imaging of glutathione S-transferase (GST) activity.
Talanta, 204, 633-640.
PMID:  31357346
DOI:  10.1016/j.talanta.2019.06.059
 
 
Mori, M.,  Fujikawa, Y.,  Kikkawa, M., Shino, M., Sawane, M., Sato, S. and Inoue, H. (2019)
A highly selective fluorogenic substrate for imaging glutathione S-transferase P1: development, cellular applicability to epigenetic studies
Chem. Commun. 55(56), 8122-8125.
PMID:  31237279
DOI:  10.1039/c9cc03064f
 
 

2018

 
 
Tsuji, G., Hattori, T., Kato, M., Hakamata,, W., Inoue, H., Naito, M., Kurihara, M., Demizu, Y., Shoda, T. (2018)
Design and synthesis of cell-permeable fluorescent nitrilotriacetic acid derivatives
Bioorg. Med. Chem. 26, 5494-5498.
PMID: 30293794
DOI: 10.1016/j.bmc.2018.09.028 
 
 
藤川 雄太, 井上 英史 (2018)
新規エクジステロイド生合成因子Noppera-boを標的とした創農薬研究
YAKUGAKU ZASSHI 138(8) 1043-1048.
Link
 
 
Yun, Y.S., Takeda, Y., Fukaya, H., Fuchino, H., Kawahara, N., Takahashi, S., Takahashi, Y., Inoue, H. (2018) 
Tetrahedron Lett. 59(29), 2813-2815.
A new ent-norabietant diterpenoid from roots of Euphorbia lathyris L.
Link
 
 
Fujikawa, Y., Nampo, T., Mori, M., Kikkawa,M., and  Inoue, H. (2018)
Talanta, 179, 845-852 
Fluorescein diacetate (FDA) and its analogue as substrates for Pi-class glutathione S-transferase (GSTP1) and their biological application.
PMID: 29310316
DOI:  10.1016/j.talanta.2017.12.010

 
 
Yun, Y.S., Noda, S, Takahashi, S., Takahashi, Y., and Inoue, H, (2018)
J. Nat. Med. 72(1), 238-245.
Piperine-like alkamides from Piper nigrum induce BDNF promoter and promote neurite outgrowth in Neuro-2a cells.
PMID: 29063362
DOI: 10.1007/s11418-017-1140-3
 
 

2017

 
 
 
 
Shoda,, T., Kato, M., Fujisato, T., Demizu, Y., Inoue, H., Naito, M., and Kurihara, M. (2017)
Med. Chem. 13(3), 206-213. 
Tamoxifen and fluvestrant hybrids showed potency as selective estrogen receptor down-regulators.
PMID: 27494098
DOI: 10.2174/1573406412666160805101408
 
 

2016

 
 
Yun, Y.S., Tajima, M., Tahahashi, S., Takahashi, Y., Umemura, M., Nakano, H., Park, H.S., and Inoue, H. (2016)
Phytother. Res. 30(10), 1689-1695.
Two alkaloids from bulbs of Lycoris sanguinea MAXIM. suppress PEPCK expression by inhibiting the phosphorylation of CREB.
PMID: 27388056
DOI: 10.1002/ptr.5676
 
 
Shoda, T., Kato, M., Fujisato, T., Misawa, T., Demizu, Y., Inoue, H., Naito, M., and Kurihara, M. (2016)
Bioorg. Med. Chem. 24, 2914-2919.
Synthesis and evaluation of raloxifene derivatives as a selective estrogenreceptor down-regulator.
PMID: 27185013
DOI: 10.1016/j.bmc.2016.04.068


Brodziak-Jarosz, L., Fujikawa, Y., Pastor-Flores, D., Kasikci, S., Jirasek P., Pitzl, S., Owen, R.W., Gerhauser, C., Amslinger, S., and Dick, T.P. (2016)

Mol Nutr Food Res. 60(4), 737-748.
A click chemistry approach identifies target proteins of xanthohumol.
PMID: 26748658
DOI: 10.1002/mnfr.201500613
 
 
Fujikawa, Y.,  Roma, L.P., Sobotta, M.C.,  Rose, A.J., Diaz, M.B., Locatelli, G.,  Breckwoldt, M.O., Misgeld, T., Kerschensteiner, M., Herzig, S., Mullerr-Decker , K., Dick, T.P. (2016)
Sci. Signal. 9(419), rs1.
Mouse redox histology using genetically encoded probes.
PMID: 26980443
DOI: 10.1126/scisignal.aad3895
 
 

2015

 
 
Fujikawa, Y., Morisaki, F., Ogura, A., Morohashi, K., Enya, S., Niwa, R., Goto, S., Kojima, H.,  Okabe, T., Nagano, T.,  and Inoue, H.  (2015)
Chem. Commun., 51, 11459-11462.
A practical fluorogenic substrate for high-throughput screening of glutathione S-transferase inhibitors.
PMID: 26090533
DOI: 10.1039/c5cc02067k
 
 
Shoda, T., Kato, M., Fujisato, T., Okuhira, K., Demizu,Y., Inoue, H., Naito, M., and Kurihara, M. (2015)
Bioorg. Med. Chem. 23, 3091-3096.
Synthesis and evaluation of tamoxifen derivatives with a long alkyl side chain as selective estrogen receptor down-regulators.
PMID: 26003343
DOI: 10.1016/j.bmc.2015.05.002
 
 

2014

 
 
Yun Y.S., Fukaya, H., Nakane, T., Takano, A., Takahashi, S., Takahashi, Y., and Inoue, H. (2014)
Org. Lett., 16, 6188-6192.
A new bis-seco-abietane diterpenoid from Hyptis crenata Pohl ex Benth.
PMID: 25412277
DOI: 10.1021/ol503086n

尹 永淑,井上英史(2014)
ウチダ和漢薬 739号,5-6
転写因子CREBを制御する天然物の探索
 
 
Shoda, T., Okuhira, K., Kato, M., Demizu,Y., Inoue, H., Naito, M., and Kurihara, M. (2014)
Bioorg. Med. Chem. Lett. 24(1), 87-89.
Design and synthesis of tamoxifen derivatives as a selective estrogen receptor down-regulator.
PMID: 24332630
DOI: 10.1016/j.bmcl.2013.11.078
 
 

2013

 
 
Yun. Y.S., Noda, S., Shigemori, G., Kuriyama, R., Takahashi, S., Umemura, M., Takahashi, Y., and Inoue, H. (2013)
Phytother. Res. 27, 906-910.
Phenolic diterpenes from rosemary suppress cAMP-responsiveness of gluconeogenic gene promoters.
PMID: 22927098
DOI: 10.1002/ptr.4794
 
 

2012

 
 
Yoshina, S., Sakaki, K., Yonezumi-Hayashi, A., Gengyo-Ando, K., Inoue, H., Iino, Y., and Mitani, S. (2012)
Mol. Biol. Cell 23(9) 1728-1749.
Identification of a novel ADAMTS9/GON-1 function for protein transport from the ER to the Golgi. 
PMID: 22419820
PMCID: PMC3338439
DOI: 10.1091/mbc.E11-10-0857

Demizu, Y., Sano, K., Terayama, N., Hakamata, W., Sato, Y., Inoue, H., Okuda, H., Kurihara, M. (2012)
Synth. Commun. 42, 1724-1730.
Solid-phase nucleophilic fluorination.
DOI: 10.1080/00397911.2010.535950
 
 

2011

 
 
Bamba, Y., Yun, Y.S., Kunugi, A., Inoue, H. (2011)
J. Nat, Med. 65, 583-587.
Compounds isolated from Curcuma aromatica Salisb. inhibit human P450 enzymes.
PMID: 21287405
DOI: 10.1007/s11418-011-0507-0
 
 

2010

Kashima, K., Sano, K., Yun, Y.S., Ina, H., Kunugi, A., and Inoue, H. (2010)
Chem. Pharm. Bull. 57(2) , 191-194.
Ovafolinin A-E, five new lignans from Lyonia ovalifolia
PMID: 20118577
DOI: 10.1248/cpb.58.191

秋山卓美,林 歩美,山崎 壮,多田敦子,杉本直樹,尹 永淑,功刀 彰,棚元憲一,河村葉子 (2010)
食品衛生学雑誌 51(5), 264-272
TLC と GC/MS を用いたテルペノイド系ガムベースの識別法
Akiyama, T., Hayashi, A., Yamazaki, T., Tada, A., Sugimoto, N., Yun, Y.S., Kunugi, A., Tanamoto, K., and Kawamura, Y. (2010)
Shokuhin Eiseigaku Zasshi, 51(5) 264-272
Identification methods of terpenoid gum bases using TLC and GC/MS.
PMID: 21071912
DOI: 10.3358/shokueishi.51.264
 
 

2009

 
 
Maruyama, M., Arisaka, N., Goto, Y., Ohsawa, Y., Inoue, H., Fujiwara, H., Hattori, A., and Tsujimoto, M. (2009)
J. Biol. Chem. 284, 34692-34702.
Histidine-379 of human laeverin/aminopeptidase Q, a non-conserved residue within the exopeptidase motif, defines its distinctive enzymatic properties.
PMID: 19819873
PMCID: PMC2787332
DOI: 10.1074/jbc.M109.066712

Tada, A., Sugimoto, N., Sato, K., Akiyama, T., Asanoma, M., Yun, Y.S., Yamazaki, T., and Tanamoto, K. (2009)
食品衛生学雑誌 Journal.  Food Hyg. Soc. Jpn., 50(1), 16-21.
既存添加物苦味料ジャマイカカッシア抽出物の成分組成に基づく基原植物の検討
Examination of original plant of Jamaica quassia extract, a natural bittering agent, based on composition of the constituents.
PMID: 19325221
DOI: 10.3358/shokueishi.50.16

Kogo, H., Takeuchi, K., Inoue, H., Kihara, H., Kojima, M., and Takahashi, K. (2009)
Biochim. Biohys. Acta (Proteins and Proteomics) 1794, 70-74.
Urea-dependent unfolding of HIV-1 protease studied by circular dichroism and small-angle X-ray scattering.

PMID: 18992856
DOI: 10.1016/j.bbapap.2008.09.022

Sakurai, Y., Inoue, H., Nishii, W., Takahashi, T., Iino, Y., Yamamoto, M., and Takahashi, K. (2009)
Biosci. Biotechnol. Biochem. 73, 21-28.
Purification and characterization of a major collagenase from Streptomyces parvulus.
PMID: 19129667
DOI: 10.1271/bbb.80357
 
 

2008

 
 
Fujikawa, Y., Urano, Y., Komatsu, T., Hanaoka, K., Kojima, H., Terai, T., Inoue, H., and Nagano, T. (2008)
J. Am. Chem. Soc. 130(44) 14533-14543.
Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase (GST) and application for activity imaging in living cells.
PMID: 18841967
DOI: 10.1021/ja802423n

Yun, Y.S., Bamba, Y., Kunugi, A., Inoue, H. (2008)
Planta Medica, 74(9), 991-992. 
Inhibition of human P450 enzymes by compounds from Curcuma aromatica Salisb.

Maruyama, K., Kamiya, N., Yun, Y.S., Kunugi, A., Yokomizo, T., and Higo, J. (2008)
CBI 8, 33-48. 
Density, diffusion, and site-dipole field of solvent around four types of flavonoid studied by molecular dynamics. 
DOI: 10.1273/cbij.8.33

Takahashi, K., Niwa, H., Yokota, N., Kubota, K., and Inoue, H. (2008)
Plant Physiol. Biochem. 46, 724-729. 
Wide tissue expression of the novel aspartic proteinase genes in Arabidopsis thaliana.
PMID:18514539
DOI: 10.1186/1471-2164-14-554

Kim, Y.T., Nishii, W., Matsushima, M., Inoue, H., Ito, H., Park, S.J., and Takahashi K. (2008) 
Biosci. Biotechnol. Biochem. 72, 905-908. 
Substrate specificities of porcine and bovine enteropeptidases toward the peptide Val-(Asp)4-Lys-Ile-Val-Gly and its analogs. 
PMID: 18323639
DOI: 10.1271/bbb.70732

Hosoya, T., Yun, Y.S., and Kunugi, A. (2008) 
Phytochemistry 69, 827-832. 
Antioxidant phenylpropanoid glycosides from the leaves of Wasabia japonica.
PMID: 17920090
DOI: 10.1016/j.phytochem.2007.08.021

杉本直樹,多田敦子,黒柳正典,米田祐子,尹 永淑,功刀 彰,佐藤恭子,山崎 壮,棚本憲一(2009)
食品衛生学雑誌,49(1), 56-62.
グレープフルーツ種子抽出物および配合製品中の合成殺菌剤の調査
Sugimoto, N., Tada, A., Kuroyanagi, M., Yoneda, Y., Yun, Y.S., Kunugi, A., Sato, K., Yamazaki, T., and Tanamoto, K. (2008) 
Shokuhin Eiseikagaku Zasshi, 49, 56-62. 
Survey of synthetic disinfectants in grapefruit seed extract and its compounded products.
PMID: 18344660
DOI: 10.3358/shokueishi.49.56 
 
 

2007

Huang, X.-P., Yabuki, Y., Kojima, M., Inoue, H., Takahashi, K. (2007)
Biol. Chem. 388, 129-133.
Activation profiles of the zymogen of aspergilloglutamic peptidase.
PMID: 17214557
DOI: 10.1515/BC.2007.014

Uekusa, Y., Sugimoto, N., Sato, K., Yun, Y.S., Kunugi, A., Yamazaki, T., Tanamoto, K. (2007)
Chem. Pharm. Bull. 55, 1643-1646.
Neocrocin A: a novel crocetin glycoside with a unique system for binding sugars isolated from gardenia yellow.
PMID: 17978528
DOI: 10.1248/cpb.55.1643
 
 

2006

Kanai, T., Takahashi, K., Inoue, H. (2006)
J. Biochem. (Tokyo).  140, 703-711.
Three distinct-type glutathione S-transferases from Escherichia coli important for defense against oxidative stress. 
PMID: 17018556
DOI: 10.1093/jb/mvj199

Gengyo-Ando, K., Yoshina, S., Inoue, H., Mitani, S. (2006)
Biochem. Biophys. Res. Commun. 349, 1345-1350.
An efficient transgenic system by TA cloning vectors and RNAi for C.elegans

PMID: 16979594
DOI: 10.1016/j.bbrc.2006.08.183

Morita, H., Eda, M., Iizuka, T., Hirasawa, Y., Sekiguchi, M., Yun, Y-S., Itokawa, H., Takeya, K. (2006)
Bioorg. Med. Chem. Lett. 16, 4458-4461
Structure of a new cyclic nonapeptide, segetalin F, and vasorelaxant activity of segetalins from Vaccaria segetalis.
PMID: 16844371
DOI: 10.1016/j.bmcl.2006.06.083
 
 
Nomura, H., Athauda, S.B.P., Wada, H., Maruyama, Y., Takahashi, K., and Inoue, H. (2006)
J. Biochem. (Tokyo) 139, 967-979.
Identification and reverse genetic analysis of mitochondrial processing peptidase and the core protein of the cytochrome bc1 complex of Caenorhabditis elegans, a model parasitic nematode.
PMID: 16788047
DOI: 10.1093/jb/mvj114