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2017年

Kojima M, Ozawa N, Mori Y, Takahashi Y, Watanabe-Kominato K, Shirai R, Watanabe R, Sato K, Matsuyama T, Ishibashi-Ueda H, Koba S, Kobayashi Y, Hirano T, Watanabe T. Catestatin prevents macrophage-driven atherosclerosis but not arterial injury-induced neointimal hyperplasia. Thromb Haemost 2017, in press.

Sato K, Shirai R, Hontani M, Shinooka R, Hasegawa A, Kichise T, Yamashita T, Yoshizawa H, Watanabe R, Matsuyama T, Ishibashi-Ueda H, Koba S, Kobayashi Y, Hirano T, Watanabe T. A potent vasoconstrictor kisspeptin-10 induces atherosclerotic plaque progression and instability: reversal by its receptor GPR54 antagonist. J Am Heart Assoc 2017, in press.

Terasaki M, Hiromura M, Mori Y, Kohashi K, Kushima H, Ohara M, Watanabe T, Andersson O, Hirano T. Combination therapy with a sodium-glucose cotransporter 2 inhibitor and a dipeptidyl peptidase-4 inhibitor additively suppresses macrophage foam cell formation and atherosclerosis in diabetic mice. Int J Endocrinol 2017, in press.

Nakano N, Tsuchiya Y, Kako K, Umezaki K, Sano K, Ikeno S, Otsuka E, Shigeta M, Nakagawa A, Sakata N, Itoh F, Nakano Y, Iemura SI, van Dinther M, Natsume T, Ten Dijke P, Itoh S. TMED10 protein interferes with transforming growth factor (TGF)-β signaling by disrupting TGF-β receptor complex formation. J Biol Chem 2017;292:4099-4112.

2016年

Mori S, Yamada H, Noguchi Y, Miyakawa T, Morikawa R, Watanabe T, Takasu M. Analysis of interaction between GLP-1 and bilayer. Peptide Science 2016;2015:339-342.

Watanabe R, Watanabe H, Takahashi Y, Kojima M, Konii H, Watanabe K, Shirai R, Sato K, Matsuyama T, Ishibashi-Ueda H, Iso Y, Koba S, Kobayashi Y, Hirano T, Watanabe T. Atheroprotective Effects of Tumor Necrosis Factor-Stimulated Gene-6. JACC Basic Transl Sci 2016, in press.

Yamamoto K, Tajima Y, Hasegawa A, Takahashi Y, Kojima M, Watanabe R, Sato K, Shichiri M, Watanabe T. Contrasting effects of stanniocalcin-related polypeptides on macrophage foam cell formation and vascular smooth muscle cell migration. Peptides. 2016; 82: 120-7.

Hiromura M, Mori Y, Kohashi K, Terasaki M, Shinmura K, Negoro T, Kawashima H, Kogure M, Wachi T, Watanabe R, Sato K, Kushima H, Tomoyasu M, Nakano Y, Yamada Y, Watanabe T, Hirano T. Suppressive effects of glucose-dependent insulinotropic polypeptide on cardiac hypertrophy and fibrosis in angiotensin II-infused mouse models. Circ J. 2016; 80: 1988-97.

Naito C, Hashimoto M, Watanabe K, Shirai R, Takahashi Y, Kojima M, Watanabe R, Sato K, Iso Y, Matsuyama T, Suzuki H, Ishibashi-Ueda H, Watanabe T. Facilitatory effects of fetuin-A on atherosclerosis. Atherosclerosis 2016; 246: 344-51.

Watanabe K, Watanabe R, Konii H, Shirai R, Sato K, Matsuyama TA, Ishibashi-Ueda H, Koba S, Kobayashi Y, Hirano T, Watanabe T. Counteractive effects of omentin-1 against atherogenesis. Cardiovasc Res. 2016; 110: 118-28.

Kohashi K, Hiromura M, Mori Y, Terasaki M, Watanabe T, Kushima H, Shinmura K, Tomoyasu M, Nagashima M, Hirano T. A dipeptidyl peptidase-4 inhibitor but not incretins suppresses abdominal aortic aneurysms in angiotensin II-infused apolipoprotein E-null mice. J Atheroscler Thromb. 2016; 23: 441-54.

2015年

Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne T, Kodama T, Aburatani H, Inagaki T, Sakai J. JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis, Nature Commun 2015;6:7052.

Ohsawa Y, Takayama K, Nishimatsu S, Okada T, Fujino M, Fukai Y, Hagiwara H, Itoh F, Tsuchida K, Hayashi Y, Sunada Y. The inhibitory core of the myostatin prodomain: its interaction with both type I and type II membrane receptors, and potential to treat muscle atrophy. PLOS ONE 2015;10:e0133713.

Takayama K, Noguchi Y, Aoki S, Takayama S, Yoshida M, Asari T, Yakushiji F, Nishimatsu S, Ohsawa Y, Itoh F, Negishi Y, Sunada Y, Hayashi Y. Identification of the minimum peptide from mouse myostatin prodomain for human myostatin inhibition. J Med Chem 2015;58:1544-1549.

Terasaki M, Hiromura M, Mori Y, Kohashi K, Nagashima M, Kushima H, Watanabe T, Hirano T. Amelioration of hyperglycemia with a sodium-glucose cotransporter 2 inhibitor prevents macrophage-driven atherosclerosis through macrophage foam cell formation suppression in type 1 and type 2 diabetic mice. PLOS ONE 2015;10:e0143396.

Furuta C, Miyamoto T, Takagi T, Noguchi Y, Kaneko J, Itoh S, Watanabe T, Itoh F. Transforming growth factor-β signaling enhancement by long-term exposure to hypoxia in a tumor microenvironment composed of Lewis lung carcinoma cells. Cancer Sci 2015;106:1524-1533.

Mori S, Yamada H, Noguchi Y, Miyakawa T, Morikawa R, Watanabe T, Takasu M. Structure analysis of GLP-1 in DPC micelle. Peptide Science 2015, in press.

2014年

Nakano N, Maeyama K, Ikeno S, Itoh F, Togawa Y, Katsu Y, Vo Nguyen TT, Watanabe Y, Kato M, Itoh, S. C18ORF1: a novel negative regulator of TGF-β signaling. J Biol Chem 2014;289:12680-12692.

Hasegawa A, Sato K, Shirai R, Watanabe R, Yamamoto K, Watanabe K, Nohtomi K, Hirano T, Watanabe T. Vasoprotective effects of urocortin 1 against atherosclerosis in vitro and in vivo. PLOS ONE 2014, in press.

Mori S, Yamada H, Fukuda M, Fukasawa Y, Miyakawa T, Morikawa R, Watanabe T, Takasu M.Structure analysis of glucagon-like peptide-1 by molecular dynamics simulation. Peptide Science 2014, in press.

Tashiro Y, Sato K, Watanabe T, Nohtomi K, Terasaki M, Nagashima M, Hirano T. A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell formation and atherosclerosis. Peptides 2014;54:19-26.

2013年

Fujimoto K, Hayashi A, Kamata Y, Ogawa A, Ichikawa R, Watanabe T, Iso Y, Koba S, Kobayashi S, Koyama T, Shichiri M. Circulating levels of human salusin-β, a potent hemodynamic and atherogenesis regulator. PLOS ONE 2013;8:e76714.

Terasaki M, Nagashima M, Nohtomi K, Kohashi K, Tomoyasu M, Sinmura K, Nogi Y, Katayama Y, Sato K, Itoh F, Watanabe T, Hirano T. Preventive effect of dipeptidyl peptidase-4 inhibitor on atherosclerosis is mainly attributable to incretin's actions in nondiabetic and diabetic apolipoprotein E-null mice. PLOS ONE 2013;8:e70933.

Konii H, Sato K, Kikuchi S, Okiyama H, Watanabe R, Hasegawa A, Yamamoto K, Itoh F, Hirano T, Watanabe T. Stimulatory effects of cardiotrophin-1 on atherosclerosis. Hypertension 2013; 62:942-950.

2012年

Sato K, Nimura A, Yamaguchi K, Akita A. Anatomical study of the proximal origin of hamstring muscles.J Orthop Sci 2012;17:614-618.

Itoh, F., Itoh, S., Adachi, T., Ichikawa, K., Matsumura, Y., Takagi, T., Festing, M., Watanabe, T., Weinstein, M., Karlsson, S., and Kato, M. Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions. Blood 119, 5320-5328 (2012).

Koya, T., Miyazaki, T., Watanabe, T., Shichiri, M., Atsumi, T., Kim-Kaneyama, J., and Miyazaki, A. Salusin-β accelerates inflammatory responses in vascular endothelial cells via NF-κB signaling in LDL receptor-deficient mice in vivo and HUVECs in vitro. Am J Physiol Heart Circ Physiol. 2012; 303: 96-105.

Nogi, Y., Nagashima, M., Terasaki, M., Nohtomi, K., Watanabe, T., and Hirano, T. Glucose-dependent insulinotropic polypeptide prevents the progression of macrophage-driven atherosclerosis in diabetic apolipoprotein E-null mice. PLOS ONE 2012;7:e35683.

Terasaki, M., Nagashima, M., Watanabe, T., Nohtomi, K., Mori, Y., Miyazaki, A., and Hirano T. Effects of PKF275-055, a dipeptidyl peptidase-4 inhibitor, on the development of atherosclerotic lesions in apolipoprotein E-null mice. Metabolism 2012;61:974-977.

2011年

Suzuki, N., Shichiri, M., Tateno, T., Sato, K., and Hirata, Y. Distinct systemic distribution of salusin-α and salusin-β in the rat. Peptides, 32, 805-810 (2011).

Yang, W., Itoh, F., Ohya, H., Kishimoto, F., Tanaka, A., Nakano, N., Itoh, S., and Kato, M. Interference of E2-2-mediated effect in endothelial cells by FAM96B through its limited expression of E2-2. Cancer Sci. 102, 1808-1814 (2011).

Nagashima, M., Watanabe, T., Terasaki, M., Tomoyasu, M., Nohtomi, K., Kim-Kaneyama, J., Miyazaki, A., and Hirano, T. Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice. Diabetologia 54, 2649-2659 (2011)

総説&著書

Watanabe T, Watanabe-Kominato K, Takahashi Y, Kojima M, Watanabe R. Adipose tissue-derived omentin-1 function and regulation. Compr Physiol 2017, in press.

Itoh F, Watabe T, Miyazono K. Roles of TGF-β family signals in the fate determination of pluripotent stem cells. Semin Cell Dev Biol 2014;32:98-106.

Watanabe T, Konii H, Sato K, Itoh F. The roles of novel vasoactive agents in atherosclerotic cardiovascular diseases: good or bad guys? Cardiovascular Disease I 2014, 117-131.

Sato K, Watanabe R, Shichiri M, Itoh F, Watanabe T. Salusins: potential use as a biomarker for atherosclerotic cardiovascular diseases. Int J Hypertens 2013;2013:965140.

Watanabe T, Sato K, Itoh F, Noguchi Y, Fujimoto K, Koyama T, Shichiri M. Emerging roles for vasoactive peptides in diagnostic and therapeutic strategies against atherosclerotic cardiovascular diseases. Curr Protein Pept Sci 2013, in press.

Watanabe, T., Sato, K., Itoh, F., and Iso, Y. Pathogenic involvement of heregulin-β1 in anti-atherogenesis. Regul. Pept., 175, 11-14 (2012).

Watanabe, T., Sato, K., Itoh, F., Wakabayashi, K., Shichiri, M., and Hirano, T. Endogenous bioactive peptides as potential biomarkers for atherosclerotic coronary heart disease. Sensors, in press (2012).

Itoh, S. and Itoh, F. Implication of TGF-β as a survival factor during tumor development. J. Biochem., in press (2012).

Iso, Y., Watanabe, T., Shoji, M., and Suzuki, H. Stem/progenitor-cell-based approach for restenosis after percutaneous coronary intervention: application of bone marrow progenitors and future perspectives. Translational Medicine, in press (2012).

Wakabayashi, K., Pakala, R., Watanabe, T., Mori, H., Iso, Y., and Suzuki, H. Novel technologies and future perspectives of drug-eluting stent. Translational Medicine, in press (2012).

Watanabe, T. and Koba, S. Roles of serotonin in atherothrombosis and related diseases. Traditional and Novel Risk Factors in Atherothrombosis, p.57-70 (2012).

Shichiri, M., Izumiyama, H., and Watanabe, T. Salusins. Handbook of Biologically Active Peptides, in press (2012).

Watanabe, T., Sato, K., Itoh, F., Iso, Y., Nagashima, M., Hirano, T., and Shichiri, M. The roles of salusins in atherosclerosis and related cardiovascular diseases. J. Am. Soc. Hypertens. 5, 359-365 (2011).

Itoh, S. and Itoh, F. Inhibitory machinery for the TGF-β family signaling pathway. Growth Factors 29, 163-173 (2011).

Sato, K., Koyama, T., and Shichiri, M. Physicochemical characteristics of salusin-β and establishment of the radioimmunoassay. Rinsho Byori 59, 121-127 (2011).

伊東史子、加藤光保、TGF-bシグナル研究―メカニズムの解明からあらたな治療へ、 別冊・医学のあゆみ 43-47 (2011).

伊東史子、胚体外血管系と造血、血管生物医学事典、朝倉書店 47-48 (2011).

伊東史子、Smad、血管生物医学事典、朝倉書店 401-402 (2011).

国際学会

Rena Watanabe, Kaho Watanabe, Remina Shirai, Hanae Konii, Kengo Sato, Takuya Watanabe. Preventive effects of tumor necrosis factor-stimulated gene-6 on atherosclerosis. American Heart Association Scientific Sessions 2014, 2014/11, Chicago, Illinois, USA.

Takuya Watanabe, Hanae Konii, Sayaka Kikuchi, Hazuki Okiyama, Rena Watanabe, Akinori Hasegawa, Keigo Yamamoto, Kengo Sato, Fumiko Itoh, Tsutomu Hirano. Stimulatory effects of cardiotrophin-1 on atherosclerosis. American Heart Association Scientific Sessions 2013, 2013/11, Dallas, Texas, USA

Michishige Terasaki, Masaharu Nagashima, Kyoko Nohtomi, Kyoko Kohashi, Masako Tomoyasu, Kyoko Ikado, Yukinori Nogi, Kengo Sato, Fumiko Itoh, Takuya Watanabe, Tsutomu Hirano. The suppressive effect of dipeptidyl peptidase-4 inhibitor on atherosclerosis is mainly attributable to the action of incretin in both nondiabetic and diabetic mice. 49th Annual Meeting of the European Association for the Study of Diabetes, 2013/9, Baecelona, Spain.

Kazumi Fujimoto, Takuya Watanabe, Masayoshi Shichiri, Takatoshi Koyama. Plasma salusin-β levels in health and atherosclerotic cardio- and cerebro-vascular diseases. International Society on Thrombosis and Haemostasis 2013, 2013/7 Amsterdam, Netherlands.

Itoh, F., Ichikawa, K., Itoh, S., Oliver, G., Karlsson, S., and Watanabe, T., TGF-・タ signaling regulates lymphangiogenesis in mice development. 第1回 先端研究拠点事業TGF-β国際シンポジウム, 2012/2, Tokyo, Japan

Itoh, F., Matsumura, Y., Takagi, T., Itoh, S., Watanabe, T., and Kato, M., Dicer-dependent miRNA pathway is important for early hematopoiesis but not for angiogenesis. 1st Asia-Pacific Vascular Biology Meeting, 2011/12, Tokyo, Japan

Itoh, F., Ichikawa, K., Itoh, S., and Watanabe, T., Involvement of TGF-β/Smad pathway in lymphangiogenesis. JSPS-NOW Joint Seminar, 2011/11 Tokyo, Japan (招待講演)

Itoh, F., Itoh, S., Watanabe, T., and Kato, M., TGF-β signaling is involved in lymphatic vessel development in vivo. FASEB Summer Research Conference, 2011/8, Lucca, Italy

Itoh, F., TGF-β signaling is involved in lymphatic vessel development in vivo. TGF-β meeting, 2011/8, Uppsala, Sweden

Tomoyasu, M., Kim-Kaneyama, J., Nagashima, M., Miyazaki, A., Watanabe, T., and Hirano, T., Native incretins suppress the proliferation and migration of vascular smooth muscle cells. 3rd Scientific Meeting of the Asian Association for the Study of Diabetes, 2011/7, Beijing, China

国内学会

Fumiko Itoh, Takahiro Takagi, Kei Ichikawa, Fruttiger Marcus, Guillermo Oliver, Susumu Itoh, Takuya Watanabe. Involvement of TGF-β signaling in tumor angiogenesis and lymphangiogenesis. 第21回 日本血管生物医学会学術集会、大阪、2013年9月26-28日.

Takuya Watanabe, Hanae Konii, Sayaka Kikuchi, Hazuki Okiyama, Rena Watanabe, Akinori Hasegawa, Keigo Yamamoto, Kengo Sato, Fumiko Itoh. Cardiotophin-1 accelerates the development of atherosclerotic lesions. 第21回 日本血管生物医学会学術集会、大阪、2013年9月26-28日.

Akinori Hasegawa, Kengo Sato, Hanae Konii, Rena Watanabe, Keigo Yamamoto, Fumiko Itoh, Takuya Watanabe. Suppressive effects of urocortin-1 on atherosclerosis. 第45回 日本動脈硬化学会学術集会、東京、2013年7月18-19日.


Keigo Yamamoto, Kengo Sato, Yukie Tajima, Akinori Hasegawa, Fumiko Itoh, Takuya Watanabe. Opposite effect of stanniocalcin-related proteins on foam cell formation in human monocyte-derived macrophages. 第45回 日本動脈硬化学会学術集会、東京、2013年7月18-19日

Takuya Watanabe, Hanae Konii, Sayaka Kikuchi, Hazuki Okiyama, Rena Watanabe, Akinori Hasegawa, Keigo Yamamoto, Kengo Sato, Fumiko Itoh, Tsutomu Hirano. Stimulatory effects of cardiotrophin-1 on atherosclerosis. 第45回 日本動脈硬化学会学術集会、東京、2013年7月18-19日

渡部琢也、新規血管作動性ペプチドと酸化LDLの動脈硬化に対する相互作用、富士吉田医師会学術講演会、2012/5、富士吉田渡部琢也、サリューシンの動脈硬化制御作用、1st Symposium on Salusins、2012/6、相模大野

寺崎道重、長嶋理晴、平野勉、渡部琢也、宮崎章、DPP-4阻害剤はア・|Eノックアウトマウスの動脈硬化進展を抑制する、第58回 昭和医学会総会、2011/11、東京

渡部琢也、生命を脅かす動脈硬化性疾患の治療戦略、大妻高校模擬講義、2011/10、東京


渡部琢也、動脈硬化は生命を脅かす怖い病気?発症メカニズムを知れば予防・治療に役立つ?、第23年度 八王子学園都市大学 いちょう塾、2011/10、東京

渡部琢也、新規血管作動性ペプチドと酸化LDLの動脈硬化に対する相互作用、第3回 Multiple Risk Investigators Conference、2011/9、東京(招待講演)

渡部琢也、生命を脅かす動脈硬化性疾患の治療戦略、東京薬科大学オープンキャンパス、2011/8、東京

伊東史子、佐藤健吾、渡部琢也、生命をむさぼる脈管系の暴走:血管研究の新展開、第1回 医薬工3大学包括連携推進シンポジウム、2011/7、東京

渡部琢也、インクレチンの抗動脈硬化作用、第6回 動脈硬化症例検討会、2011/7、東京(招待講演)

Terasaki, M., Nagashima, M., Tomoyasu, M., Kim-Kaneyama, J., Watanabe, T., Miyazaki, A., and Hirano, T., Glucose-dependent insulinotropic polypeptide suppresses the development of atherosclerosis in apolipoprotein E-null mice via its own receptors, 第43回 日本動脈硬化学会学術集会、2011/7、札幌

渡部琢也、生命医科学の最先端に触れる?生命を脅かす動脈硬化性疾患の・。療戦略?、駿台お茶の水校、2011/6、東京


長嶋理晴、寺崎道重、友安雅子、渡部琢也、宮崎章、平野勉、GIP・フ慢性持続投与はApoE欠損マウスの動脈硬化進展を抑制する、第54回 日本糖尿病学会年次学術集会、2011/5、札幌

藤本和美、佐藤健吾、七里眞義、小山高敏、動脈硬化促進因子salusin-βの分泌とELISA系の確立、第40回 日本心脈管作動物質学会、2011/2、香川