Tokyo University of Pharmacy and Life Sciences
Takuya Watanabe, MD, PhD
Fumiko Itoh, PhD
Kengo Sato, PhD
Peptide Sciences Emerge to Open Up New Therapeutic Windows Against Cardiovascular Diseases
This laboratory investigates the pathophysiological roles of vasoactive peptides and their molecular mechanisms in the formation of atherosclerosis and angiogenesis.
1) Atherosclerosis working group assesses the modulatory effects of novel peptide hormones on atherosclerosis and its related diseases. Among numerous peptides recently identified, we sorted them into two groups: good or bad for atherosclerosis. We would like to produce the peptide-based treatments, such as analogues using good ones and receptor blockers against bad ones, and diagnostic biomarkers, which will become useful in the new future clinical practice.
2) Angiogenesis working group investigates the molecular mechanisms of angiogenesis regulated by TGF-β in vivo. Further, we elucidate the role of TGF-β signaling in tumor metastases under their microenvironment.
Usui S, Iso Y, Sasai M, Mizukami T, Mori H, Watanabe T, Shioda S, Suzuki H. Kisspeptin-10 induces endothelial senescence and impaired endothelial growth. Clin Sci 2014, in press.
Tashiro Y, Sato K, Watanabe T, Nohtomi K, Terasaki M, Nagashima M, Hirano T. A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell formation and atherosclerosis. Peptides 2014, in press.
Konii H, Sato K, et al. Stimulatory effects of cardiotrophin 1 on atherosclerosis. Hypertension 2013;62:942-950.
Sato K, et al. Salusins: potential use as a biomarker for atherosclerotic cardiovascular diseases. Int J Hypertens 2013;2013:961540.
Fujimoto K, et al. Circulating levels of human salusin-β, a potent hemodynamic and atherogenesis regulator. PLoS One 2013;8:e76714.
Terasaki M, et al. Preventive effect of dipeptidyl peptidase-4 inhibitor on atherosclerosis is mainly attributable to incretin’s actions in nondiabetic and diabetic apolipoprotein E-null mice. PLoS One 2013;8:e70933.
Watanabe T, et al. Emerging roles for vasoactive peptides in diagnostic and therapeutic strategies against atherosclerotic cardiovascular diseases. Curr Protein Pept Sci 2013;14:472-480.
Shichiri M, et al. Salusins. Handbook of Biologically Active Peptides Section on Cardiovascular Peptides 2013, 1423-1427.
Sato K, et al. Utility of vasoactive substances as biomarkers for atherosclerotic coronary artery disease. JJCLA 2013;38:255-261.
Itoh F, et al. Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions. Blood 2012;119:5320-5328.
Watanabe T, et al. Endogenous bioactive peptides as biomarkers for atherosclerotic coronary heart disease. Sensors (Basel) 2012;12:4974-4985.
Nogi Y, et al. Glucose-dependent insulinotropic polypeptide prevents the progression of macrophage-driven atherosclerosis in diabetic apolipoprotein E-null mice. PLoS One 2012;7:e35683.
Koya T, et al. Salusin-β accelerates inflammatory responses in vascular endothelial cells via NF-kB signaling in LDL receptor-deficient mice in vivo and HUVECs in vitro. Am J Physiol Heart Circ Physiol 2012;303:H96-H105.
Terasaki M, et al. Preventive effects of dipeptidyl peptidase-4 inhibitor on the development of atherosclerotic lesions in apolipoprotein E-null mice. Metabolism 2012;61:974-977.
Watanabe T, et al. Pathogenic involvement of heregulin-β1 in anti-atherogenesis. Regul Peptides 2012;175:11-14.
Watanabe T, et al. Roles of serotonin in atherothrombosis and related disease. Traditional and Novel Risk Factors in Atherothrombosis 2012, 57-70.
Iso Y, et al. Stem/progenitor-cell-based approach for restenosis after percutaneous coronary intervention: application of bone marrow progenitors and future perspectives. Translational Medicine 2012;S:7 (doi.org/10.4172/2161-1025. S7-001).
Wakabayashi K, et al. Novel technologies and future perspectives of drug-eluting stent. Translational Medicine 2102;S:7 (doi.org/10.4172/2161-1025.S7-002).
Nagashima M, Watanabe T, et al. Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice. Diabetologia 2011;54:2649-2659.
Watanabe T, et al. The roles of salusins in atherosclerosis and related cardiovascular diseases. J Am Soc Hypertens 2011;5:359-365.